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KMID : 0043319820050020061
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Archives of Pharmacal Research
1982 Volume.5 No. 2 p.61 ~ p.70
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Characteristics of Ethylcellulose Microcapsules of Sulfisoxazole
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Oh DM
Lee MH
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Abstract
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Sulfisoxazole, a chemotherapeutic agent, was microencapsulated with ethylcellulose by means of phase separation from cyclohexane by temperature change. The size distribution was determined by use of standard sieves and the effect of core to wall ratio was noted. To examine their shapes and surface characteristics, the microcapsules were observed with a scanning electron microscope. Release of the drug from microcapsules into pH 7.5 buffer medium was studied. The release pattern was found to have similar properties to the release of a drug from an insoluble porous matrix reported. The apparent diffusion coefficient of sulfisoxazole was measured for the transport of the drug from the core of microcapsules into the surrounding sink condition. The apparent diffusion coefficient increased with increasing capsule size.
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